|ATTRIBUTE||ALANINE DOSIMETRY SYSTEM||RED 4034 DOSIMETRY SYSTEM|
|Instrumentation||Electron paramagnetic resonance (EPR) spectrometer||SpectrophotometerMicrometer|
|Dosimeter Description||Alanine substrate pressed into pellet shape with wax for binding material. Pellet is placed into a film package with a bar code that cannot be separated from the film package.||Polymethylmethacrylate (PMMA) molded sheets cut into ~ 3.0×1.1×0.55 mm pieces. Hermetically sealed in a film package.|
|Dosimeter contains crystalline alanine and registers the absorbed dose by the formation of alanine-derived free radicals. Identification and measurement of the alanine-derived free radicals are performed by EPR spectroscopy.ISO/ASTM 51607 Standard Practice for Use of an Alanine-EPR Dosimetry System||Induction of chemical reactions resulting from irradiation, which create absorption bands in the visible and/or UV regions of the spectrum. Optical absorbance is determined at appropriate wavelengths within these radiation-induced absorption bands and is quantitatively related to absorbed dose.ISO/ASTM 51276 Standard Practice for Use of a Polymethylmethacrylate Dosimetry System|
|Dosimeter Measurement Process||Insert alanine dosimeter into spectrometer, system automatically transfers dosimeter bar code into software and begins taking measurementDose calculated||Users remove dosimeter from packetPlace dosimeters into holder that holds 8 dosimeters
Place holder into spectrophotometer and absorbance transferred into software
Remove dosimeters from holder and read thickness of dosimeters, one at a time
Thickness automatically transferred into software
|Temperature, pellet massISO/ASTM 51607 Standard Practice for Use of an Alanine-EPR Dosimetry System||Temperature, humidity, dose rate, post-irradiation responseISO/ASTM 51276 Standard Practice for Use of a Polymethylmethacrylate Dosimetry System|
|Typical Dosimeter System Uncertainty
|± 4%ISO/ASTM 51607 Standard Practice for Use of an Alanine-EPR Dosimetry System||± 6%ISO/ASTM 51276 Standard Practice for Use of a Polymethylmethacrylate Dosimetry System|
|Typical Dose Range||0.5-150 kGy||5-50 kGy|
1 Influence quantities are compensated for by either the user or the dosimeter manufacturer.
Radiation Dose Setting: Single Lot vs. Full Validation of Minimum Sterilization Dose
This TechTip will explain the differences between single lot validations and full validations of minimum sterilization dose, and outline the advantages and disadvantages of each of these approaches to dose setting.
Overview of an E-Beam Irradiation Validation For Healthcare Products
Prior to beginning routine processing with electron beam (E-beam) irradiation, a product with a sterile claim needs to complete a validation process to ensure the sterility assurance level claimed is achieved.
Overview Of Sterilization Technology Comparison
Learn more about our global offering, which includes electron beam, gamma, X-ray, and ethylene oxide technologies